Publications

2026 Link to heading

A Bauer, A Arndt, L Reichenbach, N Gebauer, M Mueller, C Neumann, C Schulz, K Steinestel, R Heller, E Chteinberg, H Busch, A Riecke, A Kuenstner, H Witte. Adenosine Pathway Activation Defines Genetically Linked Immunosuppressive Subtypes in Solid Tumor Brain Metastases. Cancers. 2026, 18(7):1087.
Obada Taleb Alhalabi, Stefan Heene, Guoli Zheng, R Heller, Tim Schubert, Marcin Luzarowski, Xiaowei Zha, Johannes Walter, Lea Hansen-Palmus, Bahram Biglari, Xing-Jin Wang, Laura Ruebenacker, Thomas Skutella, Karl Kiening, Christian Patrick Schaaf, Sandro Manuel Krieg, Andreas Wilhelm Unterberg, Klaus Zweckberger, Alexander Younsi. Systemic Interleukin-4 Application Promotes Functional Recovery and Reprograms Neuroinflammatory and Molecular Responses after Spinal Cord Injury in Rats. Theranostics. 2026, 16(9):4726–4744.

2025 Link to heading

R Heller, M. Maares, T. Chillon, H. Witte, Obada T. Al-Halabi, Stefan Heene, A. Younsi, Patrick Haubruck, Lutz Schomburg, A. Moghaddam, B. Biglari, H. Haase. Total and Free Zinc Dynamics as Biomarkers for Neurological Impairment in Traumatic Spinal Cord Injury. Nutrients. 2025, 17(3).

2024 Link to heading

Chillon TS, Tuchtenhagen M, Schwarz M, Hackler J, R Heller, Kaghazian P, Moghaddam A, Schomburg L, Haase H, Kipp AP, Schwerdtle T, Maares M. Determination of copper status by five biomarkers in serum of healthy women. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2024, 84:127441.
K Estel, K Waldmann, S Roettel, R Heller, C Willy, DA Back. Traumatic Tear of the Pectoralis Major Muscle during Military Parachute Jumping. BMJ MILITARY HEALTH. 2024, 170(2):176–177.
R Heller, Marco Torri, Jasmin Gaab, Patrick Haubruck, Arash Moghaddam-Alvandi, Bahram Biglari. Descriptive Analysis of Surgical Outcomes and Stoma Formation for Treating Sacral and Anal Pressure Injuries in Spinal Cord Injury: A Retrospective Study of Selected Cases. SAGE Open Nursing. 2024, 10:23779608241229507.
MP Rayman, L Schomburg, JS Zhang, EW Taylor, G Du Laing, M Beck, DJ Hughes, R Heller. Could Selenium Supplementation Prevent COVID-19? A Comprehensive Review of Available Studies. MOLECULES. 2024, 29(11).

2023 Link to heading

Blenkinsop G, R Heller, Carter NJ, Burkett A, Ballard M, Tai N. Remote ultrasound diagnostics disrupting traditional military frontline healthcare delivery. BMJ military health. 2023, 169(5):456-458.
TS Chillon, K Demircan, J Hackler, R Heller, P Kaghazian, A Moghaddam, L Schomburg. Combined Copper and Zinc Deficiency Is Associated with Reduced SARS-CoV-2 Immunization Response to BNT162b2 Vaccination. HELIYON. 2023, 9(10):e20919.
P Haubruck, R Heller. Ongoing Refinement Remains Key in Dealing with Shifting Challenges in Traumatological Patient Care. ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH. 2023, 109(5):103653.
P Haubruck, R Heller, CL Blaker, EC Clarke, SM Smith, D Burkhardt, YLD Liu, S Stoner, S Zaki, CC Shu, CB Little. Streamlining Quantitative Joint-Wide Medial Femoro-Tibial Histopathological Scoring of Mouse Post-Traumatic Knee Osteoarthritis Models. OSTEOARTHRITIS AND CARTILAGE. 2023, 31(12):1602–1611.

2022 Link to heading

TS Chillon, M Maares, K Demircan, J Hackler, Q Sun, R Heller, J Diegmann, M Bachmann, A Moghaddam, H Haase, L Schomburg. Serum Free Zinc Is Associated With Vaccination Response to SARS-CoV-2. FRONTIERS IN IMMUNOLOGY. 2022, 13:906551.
K Demircan, TS Chillon, Q Sun, R Heller, GJ Klingenberg, IM Hirschbil-Bremer, P Seemann, J Diegmann, M Bachmann, A Moghaddam, L Schomburg. Humoral Immune Response to COVID-19 mRNA Vaccination in Relation to Selenium Status. REDOX BIOLOGY. 2022, 50:102242.
K Demircan, TS Chillon, T Bracken, I Bulgarelli, I Campi, G Du Laing, S Fafi-Kremer, L Fugazzola, AA Garcia, R Heller, DJ Hughes, L Ide, GJ Klingenberg, P Komarnicki, Z Krasinski, A Lescure, P Mallon, A Moghaddam, L Persani, M Petrovic, M Ruchala, M Solis, L Vandekerckhove, L Schomburg. Association of COVID-19 Mortality with Serum Selenium, Zinc and Copper: Six Observational Studies across Europe. FRONTIERS IN IMMUNOLOGY. 2022, 13:1022673.
M Maares, J Hackler, A Haupt, R Heller, M Bachmann, J Diegmann, A Moghaddam, L Schomburg, H Haase. Free Zinc as a Predictive Marker for COVID-19 Mortality Risk. Nutrients. 2022, 14(7).

2021 Link to heading

Seelig J, R Heller, Haubruck P, Sun Q, Georg Klingenberg J, Hackler J, Crowell HL, Daniel V, Moghaddam A, Schomburg L, Biglari B. Selenium-Binding Protein 1 (SELENBP1) as Biomarker for Adverse Clinical Outcome After Traumatic Spinal Cord Injury. Frontiers in neuroscience. 2021, 15:680240.
R Heller, Seelig J, Crowell HL, Pilz M, Haubruck P, Sun Q, Schomburg L, Daniel V, Moghaddam A, Biglari B. Predicting neurological recovery after traumatic spinal cord injury by time-resolved analysis of monocyte subsets. Brain : a journal of neurology. 2021, 144(10):3159-3174.
Gül-Klein S, Haxhiraj D, Seelig J, Kästner A, Hackler J, Sun Q, R Heller, Lachmann N, Pratschke J, Schmelzle M, Schomburg L. Serum Selenium Status as a Diagnostic Marker for the Prognosis of Liver Transplantation. Nutrients. 2021, 13(2).
B Biglari, R Heller, M Hörner, A Sperl, T Bock, B Reible, P Haubruck, PA Grützner, A Moghaddam. Novel Approach to an Early Assessment of a Patient's Potential for Neurological Remission after Acute Spinal Cord Injury: Analysis of Hemoglobin Concentration Dynamics. The journal of spinal cord medicine. 2021, 44(2):229–240.
T Bock, R Heller, P Haubruck, TF Raven, M Pilz, A Moghaddam, B Biglari. Pursuing More Aggressive Timelines in the Surgical Treatment of Traumatic Spinal Cord Injury (TSCI): A Retrospective Cohort Study with Subgroup Analysis. JOURNAL OF CLINICAL MEDICINE. 2021, 10(24).
TS Chillon, K Demircan, R Heller, IM Hirschbil-Bremer, J Diegmann, M Bachmann, A Moghaddam, L Schomburg. Relationship between Vitamin D Status and Antibody Response to COVID-19 mRNA Vaccination in Healthy Adults. BIOMEDICINES. 2021, 9(11).
J Hackler, R Heller, Q Sun, M Schwarzer, J Diegmann, M Bachmann, A Moghaddam, L Schomburg. Relation of Serum Copper Status to Survival in COVID-19. NUTRIENTS. 2021, 13(6).
MC Tanner, R Heller, A Grimm, S Zimmermann, M Pilz, L Jurytko, M Miska, L Helbig, G Schmidmaier, P Haubruck. The Influence of an Occult Infection on the Outcome of Autologous Bone Grafting During Surgical Bone Reconstruction: A Large Single-Center Case-Control Study. JOURNAL OF INFLAMMATION RESEARCH. 2021, 14:995–1005.

2020 Link to heading

R Heller, Sperl A, Seelig J, Haubruck P, Bock T, Werner T, Besseling A, Sun Q, Schomburg L, Moghaddam A, Biglari B. Zinc Concentration Dynamics Indicate Neurological Impairment Odds after Traumatic Spinal Cord Injury. Antioxidants (Basel, Switzerland). 2020, 9(5).
Doll J, Moghaddam A, Daniel V, Biglari B, R Heller, Schmidmaier G, Raven TF. LIPUS vs. reaming in non-union treatment: Cytokine expression course as a tool for evaluation and differentiation of non-union therapy. Journal of orthopaedics. 2020, 17:208-214.
M Belhadj, LSK Tani, ND Medjati, Y Harek, MD Sahi, Q Sun, R Heller, A Behar, L Charlet, L Schomburg. Se Status Prediction by Food Intake as Compared to Circulating Biomarkers in a West Algerian Population. NUTRIENTS. 2020, 12(12).
P Haubruck, R Heller, MC Tanner. Femoral Neck Fractures: Current Evidence, Controversies and Arising Challenges. ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH. 2020, 106(4):597–600.
P Haubruck, R Heller, MC Tanner. Fractures du col du fémur : données actuelles, controverses et nouveaux défis. Revue de Chirurgie Orthopédique et Traumatologique. 2020, 106(4):335–338.
R Heller, Qian Sun, J. Hackler, J. Seelig, Linda Seibert, Asan Cherkezov, W. Minich, P. Seemann, Joachim Diegmann, Maximilian Pilz, M. Bachmann, A. Ranjbar, A. Moghaddam, L. Schomburg. Prediction of Survival Odds in COVID-19 by Zinc, Age and Selenoprotein P as Composite Biomarker. Redox biology. 2020, 38:101764.
M Karadjian, AS Senger, C Essers, S Wilkesmann, R Heller, J Fellenberg, R Simon, F Westhauser. Human Platelet Lysate Can Replace Fetal Calf Serum as a Protein Source to Promote Expansion and Osteogenic Differentiation of Human Bone-Marrow-Derived Mesenchymal Stromal Cells. CELLS. 2020, 9(4).
A Moghaddam, R Heller, Q Sun, J Seelig, A Cherkezov, L Seibert, J Hackler, P Seemann, J Diegmann, M Pilz, M Bachmann, WB Minich, L Schomburg. Selenium Deficiency Is Associated with Mortality Risk from COVID-19. Nutrients. 2020, 12(7).
J Seelig, R Heller, J Hackler, P Haubruck, A Moghaddam, B Biglari, L Schomburg. Selenium and Copper Status - Potential Signposts for Neurological Remission after Traumatic Spinal Cord Injury. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements. 2020:126415.
T Tjardes, R Heller, D Pförringer, R Lohmann, DA Back, AG Digitalisierung DGOU. Artificial Intelligence in Orthopedics and Trauma Surgery. CHIRURG. 2020, 91(3):201–205.
H Trentzsch, G Osterhoff, R Heller, U Nienaber, M Lazarovici, DGOU, Sektion Notfall- Intensivmed Schwe, DGU. Challenges of Digitalization in Trauma Care. UNFALLCHIRURG. 2020, 123(11):843–848.
R Heller, T Bock, P Haubruck, J Seelig, A Moghaddam. Relation of Selenium Status to Neuro-Regeneration after Traumatic Spinal Cord Injury. Selenium Research for Environment and Human Health: Perspectives, Technologies and Advancements. 2020.
R Heller, J Seelig, J Hackler, P Haubruck, A Moghaddam, B Biglari, L Schomburg. Biomarkers of Selenium and Copper Status in Patients with Traumatic Spinal Cord Injury. Selenium Research for Environment and Human Health: Perspectives, Technologies and Advancements. 2020.

2019 Link to heading

R Heller, Tobias Bock, Patrick Haubruck, Julian Seelig, Arash Moghaddam. Relation of Selenium Status to Neuro-Regeneration after Traumatic Spinal Cord Injury. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements. 2019, 51:141–149.
TF Raven, A Moghaddam, C Ermisch, F Westhauser, R Heller, T Bruckner, G Schmidmaier. Use of Masquelet Technique in Treatment of Septic and Atrophic Facture Nonunion. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED. 2019, 50:40–54.
A Sperl, R Heller, B Biglari, P Haubruck, J Seelig, L Schomburg, T Bock, A Moghaddam. The Role of Magnesium in the Secondary Phase After Traumatic Spinal Cord Injury. A Prospective Clinical Observer Study. Antioxidants. 2019, 8(11).

2018 Link to heading

P Haubruck, A Solte, R Heller, V Daniel, M Tanner, A Moghaddam, G Schmidmaier, C Fischer. Chemokine Analysis as a Novel Diagnostic Modality in the Early Prediction of the Outcome of Non-Union Therapy: A Matched Pair Analysis. JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH. 2018, 13(1):249.
P Haubruck, J Ober, R Heller, M Miska, G Schmidmaier, MC Tanner. Complications and Risk Management in the Use of the Reaming-Irrigator-Aspirator (RIA) System: RIA Is a Safe and Reliable Method in Harvesting Autologous Bone Graft. PLOS ONE. 2018, 13(4):e0196051.
P Haubruck, R Heller, MC Tanner, V Daniel, G Schmidmaier, F Bolourchi, A Moghaddam, C Fischer. A Preliminary Study of Contrast-Enhanced Ultrasound (CEUS) and Cytokine Expression Analysis (CEA) as Early Predictors for the Outcome of Tibial Non-Union Therapy. DIAGNOSTICS. 2018, 8(3).
P Haubruck, R Heller, P Apitz, A Kammerer, A Alamouti, V Daniel, G Schmidmaier, A Moghaddam. Evaluation of Matrix Metalloproteases as Early Biomarkers for Bone Regeneration during the Applied Masquelet Therapy for Non-Unions. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED. 2018, 49(10):1732–1738.
R Massoud, R Heller, N Moukalled, C Matar, B Haffar, A Bazarbachi, J El-Cheikh. The Efficacy and Safety of Busulfan Dose Intensity with Fludarabine Conditioning Regimen for Patients with Acute Myeloid Leukemia Undergoing Allogeneic Stem Cell Transplantation. A Single Center Experience. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA. 2018, 18:S310-S311.
MC Tanner, R Heller, F Westhauser, M Miska, T Ferbert, C Fischer, S Gantz, G Schmidmaier, P Haubruck. Evaluation of the Clinical Effectiveness of Bioactive Glass (S53P4) in the Treatment of Non-Unions of the Tibia and Femur: Study Protocol of a Randomized Controlled Non-Inferiority Trial. TRIALS. 2018, 19(1):299.
F Westhauser, B Reible, M Höllig, R Heller, G Schmidmaier, A Moghaddam. Combining Advantages: Direct Correlation of Two-Dimensional Microcomputed Tomography Datasets onto Histomorphometric Slides to Quantify Three-Dimensional Bone Volume in Scaffolds. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. 2018, 106(7):1812–1821.

2017 Link to heading

T Ferbert, C Child, V Graeser, T Swing, M Akbar, R Heller, B Biglari, A Moghaddam. Tracking Spinal Cord Injury: Differences in Cytokine Expression of IGF-1, TGF-B1, and sCD95I Can Be Measured in Blood Samples and Correspond to Neurological Remission in a 12-Week Follow-Up. JOURNAL OF NEUROTRAUMA. 2017, 34(3):607–614.
R Heller, Tim Friedrich Raven, Tyler Swing, Kevin Kunzmann, Volker Daniel, Patrick Haubruck, Michael Akbar, Paul Alfred Grützner, Gerhard Schmidmaier, Bahram Biglari, Arash Moghaddam. CCL-2 as Possible Early Marker for Remission after Traumatic Spinal Cord Injury. Spinal cord. 2017:1002-1009.
A Moghaddam, R Heller, V Daniel, T Swing, M Akbar, HJ Gerner, B Biglari. Exploratory Study to Suggest the Possibility of MMP-8 and MMP-9 Serum Levels as Early Markers for Remission after Traumatic Spinal Cord Injury. SPINAL CORD. 2017, 55(1):8–15.

2016 Link to heading

A Moghaddam, A Sperl, R Heller, HJ Gerner, B Biglari. sCD95L in Serum after Spinal Cord Injury. SPINAL CORD. 2016, 54(11):957–960.
A Moghaddam, A Sperl, R Heller, K Kunzmann, V Graeser, M Akbar, HJ Gerner, B Biglari. Elevated Serum Insulin-Like Growth Factor 1 Levels in Patients with Neurological Remission after Traumatic Spinal Cord Injury. PLOS ONE. 2016, 11(7):e0159764.
R Heller, V Daniel, T Swing, M Akbar, HJ Gerner, B Biglari, A Moghaddam-Alvandi. P29 MMP-8 and MMP-9 Serum Levels as Possible Early Markers for Remission after Traumatic Spinal Cord Injury. Injury. 2016, 47(Suppl 5):S35.